The most common site of phyllodes tumor is the breast in general, phyllodes tumor may be classified as benign, malignant, or borderline tumor based on their behavior. No single feature is reliable to predict clinical behavior of phyllodes tumors. Phyllodes tumor pt of the breast are rare breast lesions, accounting for less than 1% of all breast tumors. Usia pasien adalah 1090 tahun namun yang terbanyak adalah pada kelompok usia 35 55tahun haagensens series. They account for less than 1% of all breast neoplasms.
Saat ini penamaan yang dipakai adalah menurut world health organisation, 1982 yaitu tumor phyllodes sebagai penamaan yang paling sesuai. Phyllodes tumor of the breast textbook of uncommon. Phyllodes tumor cystosarcoma phyllodes differential diagnoses. Most phyllodes tumors are benign not cancerous, some are malignant cancerous, and some are borderline.
Malignant phyllodes tumour with metastasis to the lung. Ultrasonography and core needle biopsy in the differential. Phyllodes tumors are biphasic fibroepithelial neoplasms of. Their unusual name comes from the greek word for leaf, because they have a. They account for less than 1% of all breast tumors and display a wide range of biological behaviors, ranging from benign to highly aggressive. The tumor is rarely found in adolescents and the elderly.
Phyllodes tumors fillodes or fullohdeez can also be spelled phylloides tumors fulloydeez. Arrows pointing to mitoses frequently talked about how many mitoses are seen on a high power field \40x field microscope\. Distribusi pada usia dibawah 20 tahun juga jarang, jika ada tampilan klinis dan histopatologinya adalah. These are rare breast tumors that start in the connective stromal tissue of the breast. Liposarcoma is a cancer that arises in fat cells in soft tissue, such as that inside the thigh or in the retroperitoneum. February 22, 2011, neoplasia 1 lecture duke university. Phyllodes filoydeez tumors are a rare form of breast tumor. An evaluation of the preoperative diagnosis and management of cystosarcoma phyllodes. The stroma is moderately cellular and the stromal cells show moderate nuclear atypia hematoxylineosin, 23. Phyllodes tumor pt is an exceptionally rare breast neoplasm representing less than 0. Spindled component may be positive for high molecular weight keratin or p63.
These tumors can reach sizes up to 40 cm in diameter see figure 1. Some doctors feel that an even wider margin of healthy tissue. The most common indication of a phyllodes tumor is a breast lump that is easy to feel. Jan 22, 2020 the most common symptom of a phyllodes tumor is a painless breast lump that you or your doctor can feel while examining the breasts. Preoperative diagnostic accuracy allows correct surgical treatment, avoiding the pitfalls of reoperation because of inadequate excision. They usually occur in middleaged to elderly women but can occur at any age.
Download a printable pdf of this information about borderline and malignant phyllodes tumours. Tumor phyllodes adalah suatu neoplasma fibroepitelial yang jarang ditemukan. Jul 04, 2016 surgery is the main treatment for phyllodes tumors of the breast. They are graded as benign, borderline or malignant based on the world health organisation who classification. Learn more about the symptoms and diagnosis of phyllodes tumors. They are graded as benign, borderline or malignant based on the world health organisation who classification, according to a constellation of 5. However, reliable differentiation of phyllodes tumour from cellular fibroadenoma remains difficult. Nov 09, 2014 tumor phyllodes tergolong dalam tumor yang jinak atau harmless, namun bunda tidak boleh lengah dan menganggapnya remeh karena tumor ini sendiri dapat berubah ganas sewaktuwaktu. Once i got surgery it came back as a phyllodes tumor that was benign. Welcome to cancer chat mcvikki although im sorry for the reason youve joined us.
Lymph node involvement is rarely described in phyllodes tumors. May 11, 2017 a phyllodes tumor is a rare tumor of the breast. In their least aggressive form, phyllodes tumors behave like benign fibroadenomas, although with a propensity to recur locally following excision without wide. Jul 07, 2018 scribd is the worlds largest social reading and publishing site. A low magnification of the primary breast phyllodes tumour with a cystic space into which stromal fronds projected. The roles of adjuvant radiotherapy and hormonal therapy remain to be defined. With the nonoperative management of fibroadenomas widely adopted, the importance of phyllodes tumours today lies in the need to differentiate them from other benign breast lesions. A phyllodes tumor of the breast is a rare fibroepithelial tumor, accounting for 0.
My doctor put both a fiberdinoma and phyllodes tumor down on the table for me because i was 19, diagnosed on sept 2012. Phyllodes tumor is an extremely rare tumor of the breast. Generally, phyllodes tumor presents as a rapidly growing and clinically benign breast lump in females within the fourth or fifth decade of life. Phyllodes tumor pt is uncommon neoplasm of breast, accounting for 0. The median age is 45 years, ranges from 10 to 86 and it is uncommon to occur in. Mar 20, 20 depending on the size of the breast and the location of the phyllodes tumor, mastectomy may also be required for tumors that are between 5 and 10 cm in diameter. Because these tumors can come back if enough normal tissue is not removed, surgery should involve removing the tumor and at least 1 cm of the surrounding tissue. Nov 15, 2019 borderline phyllodes tumor of breast is a rare tumor of the breast, which is observed in middleaged individuals mostly women. The descriptive epidemiology of malignant cystosarcoma phyllodes tumors of the breast. What is a borderline or malignant phyllodes tumour. Namanya berasal dari kata yunani sarcoma, yang berarti tumor berdaging, dan phyllo, yang berarti daun. In case of phyllodes growths, however, the classification is entirely different. Ppt phyllodes breast tumor powerpoint presentation. However, seeing as up to 70% of phyllodes tumors are benign, cystosarcoma was removed, and the tumor is now recognized simply as phyllodes tumor.
Phyllodes tumor of the breast histopathologic features, differential diagnosis, and moleculargenetic updates yanhong zhang, md. Bab i pendahuluan merupakan neoplasma jinak yang bersifat menyusup secara lokal dan mungkin ganas 1015%. Borderline and malignant phyllodes tumor metastasis rate is about 25% to 31%, while the overall rate of all phyllodes tumor metastasis being 4%. All breast lumps should be triple assessed and the diagnosis of a phyllodes. Optimising preoperative diagnosis in phyllodes tumour of. However, in the setting where additional recurrence would create significant. Phyllodes tumor of the breast genetic and rare diseases. Last month i had a partial mastectomy for a highgrade malignant phyllodes tumor. Imaging features of phyllodes tumor and fibroadenoma table 1 mammographic. Menurut samsuhidajat 2004, tumor jinak payudara terdiri dari.
While managing a giant phyllodes tumor, emphasis should be on complete extirpation of all visible tumors and breast tissue during mastectomy to minimize the chances of recurrence. The stroma is markedly cellular and the stromal cells show marked nuclear pleomorphism. Phyllodes tumors grow in the connective tissue of the breast, called the stroma. A tumor is a mass or lump of tissue that may resemble swelling. Apr 29, 2011 phyllodes tumors are uncommon and unpredictable. They have been described as early as 1774, as a giant type of fibroadenoma. Jan 19, 20 v the median size of phyllodes tumors is around 4 cm. Not all tumors are cancerous, but it is a good idea to see a doctor if one appears. If they are very large, this may require mastectomy. Organization yaitu tumor phyllodes filodes sebagai. Phyllodes tumors are most common in women in their 40s, but women of any age can have them. Phyllodes tumors follow up care by jonas wilson, ing.
Sifat ganasnya sendiri adalah hasil dari pertumbuhannya yang bisa sangat cepat dan besar sesuai dengan kondisi masingmasing penderita dan menyebabkan kulit di sekitar. From 1999 to 2003, 1010 breast lesions underwent imagingguided core needle biopsy. It is typically a large, fast growing mass that forms from the periductal stroma of the breast. Tumor phyllodes tergolong dalam tumor yang jinak atau harmless, namun bunda tidak boleh lengah dan menganggapnya remeh karena tumor ini sendiri dapat berubah ganas sewaktuwaktu. Tumor phyllodes adalah salah satu neoplasma fibroepitelial yang jarang ditemukan, sekitar kurangdari 1% dari seluruh neoplasma pada. Phyllodes tumors pts, which are rare and mostly benign in nature, are fibroepithelial tumors of the breasts. Differential diagnosis phyllodes tumor of the breast. The most common symptom of a phyllodes tumor is a painless breast lump that you or your doctor can feel while examining the breasts. Missed diagnoses of phyllodes tumor on breast biopsy. Phyllodes tumors of the breast are uncommon fibroepithelial neoplasms, typified by hypercellular stroma and elongated ducts with irregular leaflike patterns due to stromal proliferation. We present a case of a 33yearold woman affected by. Ekspresi cd117 dan ki67 pada benign, borderline dan. Populationsbased estimates indicate that the incidence of malignant pt is 2.
Wide excision or mastectomy should be performed ensuring histological clear margins. Distinction between phyllodes tumor and fibroadenoma in. The histologic characteristics of the stroma and glands typically differ from one region to the next, and so does the relationship between these components fig. Diagnosing phyllodes tumors usually involves a combination of steps, such as a physical exam, a mammogram, and a biopsy. Nov 05, 2018 malignant phyllodes tumor of breast is a rare tumor of the breast, which is observed in middleaged individuals mostly women. Phyllodes tumours are rare fibroepithelial lesions that account for less than 1% of all breast neoplasms. The malignant variant of phyllodes tumor is even lower.
Malignant phyllodes tumor of the breast with metastasis to the. Stromal component negative for high molecular weight keratin and p63. Phyllodes tumor page 1 of 4 md anderson cancer center. Phyllodes tumors are uncommon and unpredictable mayo.
Malignant tumors may require chemotherapy, radiation therapy, or immunotherapy medications to eliminate a tumor cell that still remains after treatment or to treat secondary tumors present at other parts of the body figure 1. Of these, 57 fibroadenomas and 12 phyllodes tumors were removed surgically. Phyllodes tumor of the breast is a rare biphasic fibroepithelial neoplasm that has the potential for recurrence and metastases. Phyllodes tumors of the breast american cancer society. Distant metastases in phyllodes tumours of the breast. The clinical presentation of this tumor is unilateral, and the behavior and. Bilateral and multifocal phyllodes tumours of the breast. Differentiation of phyllodes tumors versus fibroadenomas. Diagnosis and management of phyllodes tumour of the breast. However, in the setting where additional recurrence. Pdf 11 212tumor phyllodes jurnal rinaldi zainuddin. In certain areas, the proliferating fibroblasts of the phyllodes tumor remain confined to the specialized stromal compartment fig. Based on whether or not they are cancerous, these growths are distinguished into.
The value of fnac in diagnosis of phyllodes tumour remains controversial, but core needle biopsy has high sensitivity and negative predictive. Phyllodes tumors are rare breast tumors that start in the connective tissue and are most common in women in their 30s and 40s. These lumps often form in the upper outer quadrant of the breast. Insidensinya hanya sekitar 0,3%0,9% dari seluruh tumor payudara, sedangkan frekuensi lesi maligna bervariasi sekitar 5 30%. It is a rare type of cancer that bears a resemblance to fat cells when examined under a microscope. Abstract phyllodes tumors is a rare fibroepithelial neoplasm.
It occurs in females in the third and fourth decades. The difficulty in distinguishing between phyllodes tumors and benign fibroadenoma may lead to misdiagnosis. Phyllodes breast tumor joint hospital surgical grand round 26 april 2014 ng yuen shan, sandy tuen mun hospital triple assessment, in patients with phyllodes tumors. Scribd is the worlds largest social reading and publishing site. This includes the tissue and ligaments that surround the ducts. If the phyllodes tumor of the breast is benign or borderline histology, radiation therapy not routinely recommended after excision. Phyllodes tumors johns hopkins kimmel cancer center. Phyllodes tumor pt of the breast is a rare fibroepithelial neoplasm with risks of local recurrence and uncommon metastases. My oncologist said its up to me if i want radiation, since its only recently being used more frequently for this type of cancer. Borderline phyllodes tumor of breast is a rare tumor of the breast, which is observed in middleaged individuals mostly women. This allows the pathologist to tell the clinician how badly the tumor is. It is usually present as solitary unilateral tumor in one breast or rarely multifocal in or both breasts. Axillary nodal dissection is not indicated in the management of phyllodes tumors. Ppt phyllodes breast tumor powerpoint presentation free.
A free powerpoint ppt presentation displayed as a flash slide show on id. Benign phyllodes tumors with low risk features can be managed by limited excision that preserves the size and shape of the breast. Since phyllodes tumors are locally recurrent tumor especially when not excised with a clear margins and very u n p r e d i c t a b l ei ng r o w t ha n dm e t a s t a t i ca c t i v i t y,i ti sv. Phyllodes tumors account for fewer than 1% of all breast cancers. The role of the pathologist in the preoperative diagnosis of phyllodes tumours of the breast is critical to appropriate surgical planning. Tumor phyllodes meski jarang wajib diwaspadai doktersehat. Women with lifraumeni syndrome a rare, inherited genetic. Tumorigenesis tumor filodes payudara serta peranan. Phyllodes tumor is a very rare tumor of the breast, incidence being 0. A skilled pathologist is essential to the management of phyllodes tumors.
Phyllodes tumors are uncommon fibroepithelial breast tumors that are capable of a diverse range of biologic behaviors. Phyllodes tumors are uncommon and unpredictable mayo clinic. The aim of this study was to investigate patient characteristics, imaging characteristic findings, surgical treatment and outcome of phyllodes tumor. Phyllodes tumors of the breast are rare, accounting for less than 1% of all breast tumors. Insiden tumor phyllodes adalah jarang dan merupakan 0,31% dari tumor payudara wanita.
It is typically a large, bulky tumor, and tends to have multiple smaller satellites that extend beyond the main confines of the tumor. The us and needle biopsy results of a total of 64 lesions 52. Figure 1 left breast phyllodes tumour showing leaflike appearance on microscopy. Surgery is the main treatment for phyllodes tumors of the breast. The name phyllodes, which is taken from the greek language and means leaflike, refers to that fact that the tumor cells grow in a leaflike pattern.
Changes in the clinical characteristics, treatment options, and therapy outcomes in patients with phyllodes tumor of the breast during 55 years of experience. This is the case regardless of whether they are benign or malignant. Tumor phyllodes adalah neoplasma stromalepitelial yang jarang ditemui, secara histologis dibedakan menjadi benign, borderline, malignant. They tend to grow quickly, but they rarely spread outside the breast. Phyllodes tumours pts of the breast are uncommon fibroepithelial neoplasms, comprising 0. Phyllodes tumor, also known as cystosarcoma phyllodes, is a rare fibroepithelial tumor of the breast which has some resemblance to a fibroadenoma. Cd117 merupakan reseptor tirosin kinase yang terletak di membrane sel dan berperan dalam proses patogenesis suatu keganasan, sedangkan. Some benign tumors are not treated as they are not posing any health risk. It doesnt hurt to get a second look becuase regardless if its benign or melignant it seems like its just the same procedures done.
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